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Light-induced control of protein destruction by opto-PROTAC
By hijacking endogenous E3 ligase to degrade protein targets via the ubiquitin-proteasome system, PROTACs (PRoteolysis TArgeting Chimeras) provide a new strategy to inhibit protein targets that were regarded as undruggable before. However, the catalytic nature of PROTAC potentially leads to uncontro...
Autores principales: | Liu, Jing, Chen, He, Ma, Leina, He, Zhixiang, Wang, Dong, Liu, Yi, Lin, Qian, Zhang, Tinghu, Gray, Nathanael, Kaniskan, H. Ümit, Jin, Jian, Wei, Wenyi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034987/ https://www.ncbi.nlm.nih.gov/pubmed/32128407 http://dx.doi.org/10.1126/sciadv.aay5154 |
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