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Molecular Engineering of Adeno-Associated Virus Capsid Improves Its Therapeutic Gene Transfer in Murine Models of Hemophilia and Retinal Degeneration

Recombinant adeno-associated virus (AAV)-based gene therapy has been promising, but several host-related transduction or immune challenges remain. For this mode of therapy to be widely applicable, it is crucial to develop high transduction and permeating vectors that infect the target at significant...

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Detalles Bibliográficos
Autores principales:	Mary, Bertin, Maurya, Shubham, Kumar, Mohit, Bammidi, Sridhar, Kumar, Vikas, Jayandharan, Giridhara R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035104/ https://www.ncbi.nlm.nih.gov/pubmed/31596095 http://dx.doi.org/10.1021/acs.molpharmaceut.9b00959

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