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Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications
Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035142/ https://www.ncbi.nlm.nih.gov/pubmed/32110008 http://dx.doi.org/10.2147/IJN.S237544 |
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author | Guan, Baozhang Zhang, Xingwang |
author_facet | Guan, Baozhang Zhang, Xingwang |
author_sort | Guan, Baozhang |
collection | PubMed |
description | Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery. |
format | Online Article Text |
id | pubmed-7035142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-70351422020-02-27 Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications Guan, Baozhang Zhang, Xingwang Int J Nanomedicine Review Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery. Dove 2020-02-17 /pmc/articles/PMC7035142/ /pubmed/32110008 http://dx.doi.org/10.2147/IJN.S237544 Text en © 2020 Guan and Zhang. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Guan, Baozhang Zhang, Xingwang Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title | Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title_full | Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title_fullStr | Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title_full_unstemmed | Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title_short | Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications |
title_sort | aptamers as versatile ligands for biomedical and pharmaceutical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035142/ https://www.ncbi.nlm.nih.gov/pubmed/32110008 http://dx.doi.org/10.2147/IJN.S237544 |
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