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Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Herein, we report 3-bromo-5-methylene pyrrolones (3Br-5MPs) as a simple, robust, and versatile class of...

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Detalles Bibliográficos
Autores principales:	Zhang, Yingqian, Zang, Chuanlong, An, Guoce, Shang, Mengdi, Cui, Zenghui, Chen, Gong, Xi, Zhen, Zhou, Chuanzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035330/ https://www.ncbi.nlm.nih.gov/pubmed/32081914 http://dx.doi.org/10.1038/s41467-020-14757-4

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