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Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men

Human papillomavirus (HPV) infection contributes to most anal cancers and premalignant intraepithelial lesions. This study investigated anal HPV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviors were collected by usi...

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Autores principales: Wu, Ping-Feng, Hang, Jen-Fan, Strong, Carol, Chen, Su-Jung, Lin, Li-Ya, Chen, Shu-Sheng, Lai, Chiung-Ru, Ku, Stephane Wen-Wei, Lee, Mei-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035349/
https://www.ncbi.nlm.nih.gov/pubmed/32081941
http://dx.doi.org/10.1038/s41598-020-59967-4
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author Wu, Ping-Feng
Hang, Jen-Fan
Strong, Carol
Chen, Su-Jung
Lin, Li-Ya
Chen, Shu-Sheng
Lai, Chiung-Ru
Ku, Stephane Wen-Wei
Lee, Mei-Hsuan
author_facet Wu, Ping-Feng
Hang, Jen-Fan
Strong, Carol
Chen, Su-Jung
Lin, Li-Ya
Chen, Shu-Sheng
Lai, Chiung-Ru
Ku, Stephane Wen-Wei
Lee, Mei-Hsuan
author_sort Wu, Ping-Feng
collection PubMed
description Human papillomavirus (HPV) infection contributes to most anal cancers and premalignant intraepithelial lesions. This study investigated anal HPV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviors were collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HPV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27–3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HPV vaccine.
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spelling pubmed-70353492020-02-28 Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men Wu, Ping-Feng Hang, Jen-Fan Strong, Carol Chen, Su-Jung Lin, Li-Ya Chen, Shu-Sheng Lai, Chiung-Ru Ku, Stephane Wen-Wei Lee, Mei-Hsuan Sci Rep Article Human papillomavirus (HPV) infection contributes to most anal cancers and premalignant intraepithelial lesions. This study investigated anal HPV infections and cytological abnormalities among men who have sex with men (MSM). Sociodemographic characteristics and sexual behaviors were collected by using a structured questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV Genotyping test. Logistic regression was used to estimate risk factors and their associations with high-risk HPV infection and cytological abnormalities. Among 163 MSM, 101 were seropositive for human immunodeficiency virus (HIV) and 62 were seronegative for HIV. The overall prevalence of HPV was 66.2%. A total of 61.9% and 48.2% of participants had never acquired any of either the quadrivalent or nonavalent vaccine HPV types, respectively. Cytological findings showed 15.3% atypical squamous cells of undetermined significance, 16.6% low-grade squamous intraepithelial lesion, 4.9% atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion and 17% high-grade squamous intraepithelial lesion. The number of high-risk HPV types was the predominant risk factor for abnormal anal cytology (OR 2.02, 95% CI 1.27–3.24). Infection with high-risk HPV was a significant predictor for cytological abnormality. MSM should be encouraged to obtain the HPV vaccine. Nature Publishing Group UK 2020-02-21 /pmc/articles/PMC7035349/ /pubmed/32081941 http://dx.doi.org/10.1038/s41598-020-59967-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Ping-Feng
Hang, Jen-Fan
Strong, Carol
Chen, Su-Jung
Lin, Li-Ya
Chen, Shu-Sheng
Lai, Chiung-Ru
Ku, Stephane Wen-Wei
Lee, Mei-Hsuan
Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title_full Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title_fullStr Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title_full_unstemmed Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title_short Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
title_sort anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035349/
https://www.ncbi.nlm.nih.gov/pubmed/32081941
http://dx.doi.org/10.1038/s41598-020-59967-4
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