Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis

Atherosclerosis is a multifactorial disease of the vasculature, and shear stress is a crucial regulator of its process. Disturbed flow promotes atherosclerotic effects, while laminar flow has a protective action on the endothelium. Hippo/YAP is a major cascade that senses various mechanical cues and...

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Detalles Bibliográficos
Autores principales: Yuan, Ping, Hu, Qiongying, He, Xuemei, Long, Yang, Song, Xueqin, Wu, Fei, He, Yanzheng, Zhou, Xiangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035362/
https://www.ncbi.nlm.nih.gov/pubmed/32081881
http://dx.doi.org/10.1038/s41419-020-2343-1

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