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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion
MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1–MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In hum...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035508/ https://www.ncbi.nlm.nih.gov/pubmed/32015124 http://dx.doi.org/10.1073/pnas.1914718117 |