Cargando…

Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Gui, Xianhua, Qiu, Xiaohua, Xie, Miaomiao, Tian, Yaqiong, Min, Cao, Huang, Mei, Hongyan, Wu, Chen, Tingting, Zhang, Xin, Chen, Jingyu, Cao, Mengshu, Cai, Hourong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035537/
https://www.ncbi.nlm.nih.gov/pubmed/32104688
http://dx.doi.org/10.1155/2020/3424208
_version_ 1783500078731755520
author Gui, Xianhua
Qiu, Xiaohua
Xie, Miaomiao
Tian, Yaqiong
Min, Cao
Huang, Mei
Hongyan, Wu
Chen, Tingting
Zhang, Xin
Chen, Jingyu
Cao, Mengshu
Cai, Hourong
author_facet Gui, Xianhua
Qiu, Xiaohua
Xie, Miaomiao
Tian, Yaqiong
Min, Cao
Huang, Mei
Hongyan, Wu
Chen, Tingting
Zhang, Xin
Chen, Jingyu
Cao, Mengshu
Cai, Hourong
author_sort Gui, Xianhua
collection PubMed
description BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potential prognostic value in acute exacerbation and mortality in IPF. METHODS: Thirty-two patients with AE-IPF, 39 with S-IPF, and 20 healthy controls were included. Serum OPN and KL-6 levels were compared between AE-IPF and S-IPF. Logistic regression analysis was applied to identify the predicted value of OPN for AE. Kaplan–Meier curves were used to display survival, and Cox proportional hazards regression was used to identify risk for mortality. RESULTS: In AE-IPF patients, serum OPN levels were significantly higher than in S-IPF subjects (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls ( CONCLUSION: Elevated OPN could be a potential serum predictor for AE status and survival in IPF patients.
format Online
Article
Text
id pubmed-7035537
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-70355372020-02-26 Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis Gui, Xianhua Qiu, Xiaohua Xie, Miaomiao Tian, Yaqiong Min, Cao Huang, Mei Hongyan, Wu Chen, Tingting Zhang, Xin Chen, Jingyu Cao, Mengshu Cai, Hourong Biomed Res Int Research Article BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potential prognostic value in acute exacerbation and mortality in IPF. METHODS: Thirty-two patients with AE-IPF, 39 with S-IPF, and 20 healthy controls were included. Serum OPN and KL-6 levels were compared between AE-IPF and S-IPF. Logistic regression analysis was applied to identify the predicted value of OPN for AE. Kaplan–Meier curves were used to display survival, and Cox proportional hazards regression was used to identify risk for mortality. RESULTS: In AE-IPF patients, serum OPN levels were significantly higher than in S-IPF subjects (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls ( CONCLUSION: Elevated OPN could be a potential serum predictor for AE status and survival in IPF patients. Hindawi 2020-02-10 /pmc/articles/PMC7035537/ /pubmed/32104688 http://dx.doi.org/10.1155/2020/3424208 Text en Copyright © 2020 Xianhua Gui et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gui, Xianhua
Qiu, Xiaohua
Xie, Miaomiao
Tian, Yaqiong
Min, Cao
Huang, Mei
Hongyan, Wu
Chen, Tingting
Zhang, Xin
Chen, Jingyu
Cao, Mengshu
Cai, Hourong
Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title_full Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title_fullStr Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title_full_unstemmed Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title_short Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
title_sort prognostic value of serum osteopontin in acute exacerbation of idiopathic pulmonary fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035537/
https://www.ncbi.nlm.nih.gov/pubmed/32104688
http://dx.doi.org/10.1155/2020/3424208
work_keys_str_mv AT guixianhua prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT qiuxiaohua prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT xiemiaomiao prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT tianyaqiong prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT mincao prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT huangmei prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT hongyanwu prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT chentingting prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT zhangxin prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT chenjingyu prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT caomengshu prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis
AT caihourong prognosticvalueofserumosteopontininacuteexacerbationofidiopathicpulmonaryfibrosis