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Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potentia...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035537/ https://www.ncbi.nlm.nih.gov/pubmed/32104688 http://dx.doi.org/10.1155/2020/3424208 |
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author | Gui, Xianhua Qiu, Xiaohua Xie, Miaomiao Tian, Yaqiong Min, Cao Huang, Mei Hongyan, Wu Chen, Tingting Zhang, Xin Chen, Jingyu Cao, Mengshu Cai, Hourong |
author_facet | Gui, Xianhua Qiu, Xiaohua Xie, Miaomiao Tian, Yaqiong Min, Cao Huang, Mei Hongyan, Wu Chen, Tingting Zhang, Xin Chen, Jingyu Cao, Mengshu Cai, Hourong |
author_sort | Gui, Xianhua |
collection | PubMed |
description | BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potential prognostic value in acute exacerbation and mortality in IPF. METHODS: Thirty-two patients with AE-IPF, 39 with S-IPF, and 20 healthy controls were included. Serum OPN and KL-6 levels were compared between AE-IPF and S-IPF. Logistic regression analysis was applied to identify the predicted value of OPN for AE. Kaplan–Meier curves were used to display survival, and Cox proportional hazards regression was used to identify risk for mortality. RESULTS: In AE-IPF patients, serum OPN levels were significantly higher than in S-IPF subjects (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls ( CONCLUSION: Elevated OPN could be a potential serum predictor for AE status and survival in IPF patients. |
format | Online Article Text |
id | pubmed-7035537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70355372020-02-26 Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis Gui, Xianhua Qiu, Xiaohua Xie, Miaomiao Tian, Yaqiong Min, Cao Huang, Mei Hongyan, Wu Chen, Tingting Zhang, Xin Chen, Jingyu Cao, Mengshu Cai, Hourong Biomed Res Int Research Article BACKGROUND: Acute exacerbation (AE) is a common cause of rapid deterioration and high mortality in idiopathic pulmonary fibrosis (IPF) patients. Osteopontin (OPN) plays an important role in IPF, but the studies about serum OPN in AE-IPF are unclear. We aimed to investigate whether OPN had a potential prognostic value in acute exacerbation and mortality in IPF. METHODS: Thirty-two patients with AE-IPF, 39 with S-IPF, and 20 healthy controls were included. Serum OPN and KL-6 levels were compared between AE-IPF and S-IPF. Logistic regression analysis was applied to identify the predicted value of OPN for AE. Kaplan–Meier curves were used to display survival, and Cox proportional hazards regression was used to identify risk for mortality. RESULTS: In AE-IPF patients, serum OPN levels were significantly higher than in S-IPF subjects (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls (p < 0.001) or healthy controls ( CONCLUSION: Elevated OPN could be a potential serum predictor for AE status and survival in IPF patients. Hindawi 2020-02-10 /pmc/articles/PMC7035537/ /pubmed/32104688 http://dx.doi.org/10.1155/2020/3424208 Text en Copyright © 2020 Xianhua Gui et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gui, Xianhua Qiu, Xiaohua Xie, Miaomiao Tian, Yaqiong Min, Cao Huang, Mei Hongyan, Wu Chen, Tingting Zhang, Xin Chen, Jingyu Cao, Mengshu Cai, Hourong Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title | Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title_full | Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title_fullStr | Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title_full_unstemmed | Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title_short | Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
title_sort | prognostic value of serum osteopontin in acute exacerbation of idiopathic pulmonary fibrosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035537/ https://www.ncbi.nlm.nih.gov/pubmed/32104688 http://dx.doi.org/10.1155/2020/3424208 |
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