Kv2.1 channels play opposing roles in regulating membrane potential, Ca(2+) channel function, and myogenic tone in arterial smooth muscle

The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K(+) channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type Ca(V)1.2 channels, lowering intracellular Ca(2+) ([Ca(2+)](i)) and causing smooth mus...

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Detalles Bibliográficos
Autores principales: O’Dwyer, Samantha C., Palacio, Stephanie, Matsumoto, Collin, Guarina, Laura, Klug, Nicholas R., Tajada, Sendoa, Rosati, Barbara, McKinnon, David, Trimmer, James S., Santana, L. Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035623/
https://www.ncbi.nlm.nih.gov/pubmed/32015129
http://dx.doi.org/10.1073/pnas.1917879117

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