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Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma
BACKGROUND: Rosai-Dorfman disease is a histiocytic lesion that affects lung rarely. CASE PRESENTATION: We present a 52-year-old female diagnosed with right intrabronchial mass invading the bronchial wall and the extrabronchial tissues with lymphadenopathy. Multiple bronchoscopic biopsies were not di...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035635/ https://www.ncbi.nlm.nih.gov/pubmed/32085787 http://dx.doi.org/10.1186/s13019-020-1085-6 |
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author | Al-Maghrabi, Haneen Elmahrouk, Ahmed Feteih, Maun Jamjoom, Ahmed Al-Maghrabi, Jaudah |
author_facet | Al-Maghrabi, Haneen Elmahrouk, Ahmed Feteih, Maun Jamjoom, Ahmed Al-Maghrabi, Jaudah |
author_sort | Al-Maghrabi, Haneen |
collection | PubMed |
description | BACKGROUND: Rosai-Dorfman disease is a histiocytic lesion that affects lung rarely. CASE PRESENTATION: We present a 52-year-old female diagnosed with right intrabronchial mass invading the bronchial wall and the extrabronchial tissues with lymphadenopathy. Multiple bronchoscopic biopsies were not diagnostic. Pneumonectomy was performed and postoperative histology revealed marked mucin impaction and bronchial dilatation. The pulmonary tissue showed areas of hemorrhage and chronic inflammation. The mass exhibited an excessive number of lymphocytes, plasma cells, and numerous histiocytes engulfing them (lymphocytophagocytosis). These histiocytes were S100 protein and CD68 positive. These features are consistent with Rosai-Dorfman disease. CONCLUSION: Rosai-Dorfman Disease with pulmonary affection can be misdiagnosed as malignancy. Careful histological examination of the specimen for emperipolesis or lymphocytophagocytosis together with S100 protein and CD68 positivity are the clue for proper diagnosis. |
format | Online Article Text |
id | pubmed-7035635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70356352020-02-27 Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma Al-Maghrabi, Haneen Elmahrouk, Ahmed Feteih, Maun Jamjoom, Ahmed Al-Maghrabi, Jaudah J Cardiothorac Surg Case Report BACKGROUND: Rosai-Dorfman disease is a histiocytic lesion that affects lung rarely. CASE PRESENTATION: We present a 52-year-old female diagnosed with right intrabronchial mass invading the bronchial wall and the extrabronchial tissues with lymphadenopathy. Multiple bronchoscopic biopsies were not diagnostic. Pneumonectomy was performed and postoperative histology revealed marked mucin impaction and bronchial dilatation. The pulmonary tissue showed areas of hemorrhage and chronic inflammation. The mass exhibited an excessive number of lymphocytes, plasma cells, and numerous histiocytes engulfing them (lymphocytophagocytosis). These histiocytes were S100 protein and CD68 positive. These features are consistent with Rosai-Dorfman disease. CONCLUSION: Rosai-Dorfman Disease with pulmonary affection can be misdiagnosed as malignancy. Careful histological examination of the specimen for emperipolesis or lymphocytophagocytosis together with S100 protein and CD68 positivity are the clue for proper diagnosis. BioMed Central 2020-02-21 /pmc/articles/PMC7035635/ /pubmed/32085787 http://dx.doi.org/10.1186/s13019-020-1085-6 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Al-Maghrabi, Haneen Elmahrouk, Ahmed Feteih, Maun Jamjoom, Ahmed Al-Maghrabi, Jaudah Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title | Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title_full | Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title_fullStr | Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title_full_unstemmed | Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title_short | Rosai-Dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
title_sort | rosai-dorfman disease with pulmonary involvement mimicking bronchogenic carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035635/ https://www.ncbi.nlm.nih.gov/pubmed/32085787 http://dx.doi.org/10.1186/s13019-020-1085-6 |
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