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Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis

OBJECTIVES: To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. METHODS: PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dem...

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Autores principales: Xu, Wei, Tan, Chen-Chen, Zou, Juan-Juan, Cao, Xi-Peng, Tan, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035682/
https://www.ncbi.nlm.nih.gov/pubmed/31879285
http://dx.doi.org/10.1136/jnnp-2019-321896
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author Xu, Wei
Tan, Chen-Chen
Zou, Juan-Juan
Cao, Xi-Peng
Tan, Lan
author_facet Xu, Wei
Tan, Chen-Chen
Zou, Juan-Juan
Cao, Xi-Peng
Tan, Lan
author_sort Xu, Wei
collection PubMed
description OBJECTIVES: To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. METHODS: PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robust error meta-regression model was used to conduct the dose–response meta-analysis for sleep duration. RESULTS: 11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration. CONCLUSIONS: Sleep management might serve as a promising target for dementia prevention.
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spelling pubmed-70356822020-03-03 Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis Xu, Wei Tan, Chen-Chen Zou, Juan-Juan Cao, Xi-Peng Tan, Lan J Neurol Neurosurg Psychiatry Cognitive Neurology OBJECTIVES: To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. METHODS: PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robust error meta-regression model was used to conduct the dose–response meta-analysis for sleep duration. RESULTS: 11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration. CONCLUSIONS: Sleep management might serve as a promising target for dementia prevention. BMJ Publishing Group 2020-03 2019-12-26 /pmc/articles/PMC7035682/ /pubmed/31879285 http://dx.doi.org/10.1136/jnnp-2019-321896 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Cognitive Neurology
Xu, Wei
Tan, Chen-Chen
Zou, Juan-Juan
Cao, Xi-Peng
Tan, Lan
Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title_full Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title_fullStr Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title_full_unstemmed Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title_short Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
title_sort sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
topic Cognitive Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035682/
https://www.ncbi.nlm.nih.gov/pubmed/31879285
http://dx.doi.org/10.1136/jnnp-2019-321896
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