Cargando…

Effect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials

OBJECTIVE: To investigate the efficacy of rovatirelin, a thyrotropin-releasing hormone analogue, for ataxias in patients with spinocerebellar degeneration (SCD). METHODS: Two multicentre, randomised, double-blind, placebo-controlled phase 3 studies (KPS1301, KPS1305) enrolled patients with predomina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nishizawa, Masatoyo, Onodera, Osamu, Hirakawa, Akihiro, Shimizu, Yoshitaka, Yamada, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Neurodegeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035688/ https://www.ncbi.nlm.nih.gov/pubmed/31937586 http://dx.doi.org/10.1136/jnnp-2019-322168

Ejemplares similares

Doxycycline in early CJD: a double-blinded randomised phase II and observational study
por: Varges, Daniela, et al.
Publicado: (2017)

Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations
por: Bede, Peter, et al.
Publicado: (2021)

Peer support and reminiscence therapy for people with dementia and their family carers: a factorial pragmatic randomised trial
por: Charlesworth, Georgina, et al.
Publicado: (2016)

Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
por: Kanouchi, Tadashi, et al.
Publicado: (2012)

Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures
por: Bonilha, Leonardo, et al.
Publicado: (2012)

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans
por: Maccecchini, Maria L, et al.
Publicado: (2012)

An algorithmic approach to structural imaging in dementia
por: Harper, Lorna, et al.
Publicado: (2014)

Validation of the new consensus criteria for the diagnosis of corticobasal degeneration
por: Alexander, S K, et al.
Publicado: (2014)

Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
por: Magdalinou, Nadia, et al.
Publicado: (2014)

Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort
por: Berge, Guro, et al.
Publicado: (2014)

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey
por: Turner, Martin R, et al.
Publicado: (2015)

Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study
por: Lu, Ching-Hua, et al.
Publicado: (2015)

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
por: Turner, Martin R, et al.
Publicado: (2016)

Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records
por: Evans, Stephen JW, et al.
Publicado: (2013)

Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights
por: Vucic, Steve, et al.
Publicado: (2013)

ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials
por: Wang, Jinping, et al.
Publicado: (2016)

Quantitative EEG parameters correlate with the progression of human prion diseases
por: Franko, Edit, et al.
Publicado: (2016)

Neuronal network disintegration: common pathways linking neurodegenerative diseases
por: Ahmed, Rebekah M, et al.
Publicado: (2016)

A clinical tool for predicting survival in ALS
por: Knibb, Jonathan A, et al.
Publicado: (2016)

Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion
por: Westeneng, Henk-Jan, et al.
Publicado: (2016)

Flavour identification in frontotemporal lobar degeneration
por: Omar, Rohani, et al.
Publicado: (2013)

Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis
por: Harper, Lorna, et al.
Publicado: (2017)

Genetic screening in sporadic ALS and FTD
por: Turner, Martin R, et al.
Publicado: (2017)

Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker
por: Kassubek, Jan, et al.
Publicado: (2018)

Laughter, crying and sadness in ALS
por: Thakore, Nimish J, et al.
Publicado: (2017)

Plasma α-synuclein predicts cognitive decline in Parkinson’s disease
por: Lin, Chin-Hsien, et al.
Publicado: (2017)

Imaging and CSF analyses effectively distinguish CJD from its mimics
por: Rudge, Peter, et al.
Publicado: (2018)

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression
por: Thompson, Andrew Geoffrey Bourne, et al.
Publicado: (2018)

Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
por: Makaretz, Sara J, et al.
Publicado: (2018)

Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes
por: Forsberg, Karin, et al.
Publicado: (2019)

Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS
por: Broad, Rebecca J, et al.
Publicado: (2019)

Epidemiology of ALS in Korea using nationwide big data
por: Jun, Kyo Yeon, et al.
Publicado: (2019)

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’
por: Khalaf, Roaya, et al.
Publicado: (2019)

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest
por: Foiani, Martha S, et al.
Publicado: (2019)

Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
por: Mehta, Puja R, et al.
Publicado: (2019)

Retrotransposons in the development and progression of amyotrophic lateral sclerosis
por: Savage, Abigail L, et al.
Publicado: (2019)

Platelet abnormalities in Huntington’s disease
por: Denis, Hélèna L, et al.
Publicado: (2019)

Beyond motor neurons: expanding the clinical spectrum in Kennedy’s disease
por: Manzano, Raquel, et al.
Publicado: (2018)

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains
por: Keogh, Michael J, et al.
Publicado: (2018)

Plasma tau is increased in frontotemporal dementia
por: Foiani, Martha S, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1201uubjigd49mkjjakjmsp88t