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Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases

Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors. There is an unmet need for a potent tool to inhibit BSHs acros...

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Detalles Bibliográficos
Autores principales:	Adhikari, Arijit A., Seegar, Tom C. M., Ficarro, Scott B., McCurry, Megan D., Ramachandran, Deepti, Yao, Lina, Chaudhari, Snehal N., Ndousse-Fetter, Sula, Banks, Alexander S., Marto, Jarrod A., Blacklow, Stephen C., Devlin, A. Sloan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036035/ https://www.ncbi.nlm.nih.gov/pubmed/32042200 http://dx.doi.org/10.1038/s41589-020-0467-3

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