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The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study
OBJECTIVE: To determine the effect on the need for transfusion when intravenous tranexamic acid (TXA) is administered intraoperatively in patients undergoing total hip arthroplasty (THA). METHOD: A prospective, double blinded, randomised control trial of 88 patients undergoing THA was randomly alloc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036088/ https://www.ncbi.nlm.nih.gov/pubmed/32095290 http://dx.doi.org/10.1155/2020/2943827 |
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author | Chin, J. Blackett, J. Kieser, D. C. Frampton, C. Hooper, G. |
author_facet | Chin, J. Blackett, J. Kieser, D. C. Frampton, C. Hooper, G. |
author_sort | Chin, J. |
collection | PubMed |
description | OBJECTIVE: To determine the effect on the need for transfusion when intravenous tranexamic acid (TXA) is administered intraoperatively in patients undergoing total hip arthroplasty (THA). METHOD: A prospective, double blinded, randomised control trial of 88 patients undergoing THA was randomly allocated to receive 1 g of intravenous TXA or normal saline on induction of anaesthesia. All patients received spinal anaesthesia. The primary outcome measure was transfusion rate, and the secondary outcomes were intraoperative blood loss, haemoglobin levels, length of hospital stay, functional scores, and thromboembolic complications. RESULTS: 19.0% of patients given TXA required a blood transfusion, compared with 20.5% given placebo (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group ( CONCLUSIONS: 1 g IV TXA administered on induction did not significantly reduce the need for blood transfusion, postoperative blood loss, functional scores, or the length of stay in patients undergoing THA. This trial is registered with ACTRN12610001065088. |
format | Online Article Text |
id | pubmed-7036088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70360882020-02-24 The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study Chin, J. Blackett, J. Kieser, D. C. Frampton, C. Hooper, G. Adv Orthop Clinical Study OBJECTIVE: To determine the effect on the need for transfusion when intravenous tranexamic acid (TXA) is administered intraoperatively in patients undergoing total hip arthroplasty (THA). METHOD: A prospective, double blinded, randomised control trial of 88 patients undergoing THA was randomly allocated to receive 1 g of intravenous TXA or normal saline on induction of anaesthesia. All patients received spinal anaesthesia. The primary outcome measure was transfusion rate, and the secondary outcomes were intraoperative blood loss, haemoglobin levels, length of hospital stay, functional scores, and thromboembolic complications. RESULTS: 19.0% of patients given TXA required a blood transfusion, compared with 20.5% given placebo (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group (p=0.87). Secondary outcomes included mean intraoperative blood loss, which was 536.5 ml in the TXA group and 469.8 ml in the placebo group ( CONCLUSIONS: 1 g IV TXA administered on induction did not significantly reduce the need for blood transfusion, postoperative blood loss, functional scores, or the length of stay in patients undergoing THA. This trial is registered with ACTRN12610001065088. Hindawi 2020-02-11 /pmc/articles/PMC7036088/ /pubmed/32095290 http://dx.doi.org/10.1155/2020/2943827 Text en Copyright © 2020 J. Chin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Chin, J. Blackett, J. Kieser, D. C. Frampton, C. Hooper, G. The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title | The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title_full | The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title_fullStr | The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title_full_unstemmed | The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title_short | The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study |
title_sort | value of routine intravenous tranexamic acid in total hip arthroplasty: a preliminary study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036088/ https://www.ncbi.nlm.nih.gov/pubmed/32095290 http://dx.doi.org/10.1155/2020/2943827 |
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