Cargando…

Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study

Background: Hepatitis D virus (HDV) is a defective RNA pathogen that requires the presence of the hepatitis B virus (HBV) for infection. Middle East countries are endemic areas for HDV infection. So, it is important to estimate the prevalence of HDV in these countries. This study aimed to estimate t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pouri, Ali Asghar, Ghojazadeh, Morteza, Baiaz, Babak, Hamzavi, Fatemeh Soghra, Pourasghari, Behrouz, Somi, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036205/
https://www.ncbi.nlm.nih.gov/pubmed/32104655
http://dx.doi.org/10.15171/hpp.2020.07
_version_ 1783500178179751936
author Pouri, Ali Asghar
Ghojazadeh, Morteza
Baiaz, Babak
Hamzavi, Fatemeh Soghra
Pourasghari, Behrouz
Somi, Mohammad Hossein
author_facet Pouri, Ali Asghar
Ghojazadeh, Morteza
Baiaz, Babak
Hamzavi, Fatemeh Soghra
Pourasghari, Behrouz
Somi, Mohammad Hossein
author_sort Pouri, Ali Asghar
collection PubMed
description Background: Hepatitis D virus (HDV) is a defective RNA pathogen that requires the presence of the hepatitis B virus (HBV) for infection. Middle East countries are endemic areas for HDV infection. So, it is important to estimate the prevalence of HDV in these countries. This study aimed to estimate the prevalence of HDV in HBsAg positive patients participated in Azar cohort study, North-west of Iran. Methods: In this cross-sectional study, out of 4949 participants of the Azar cohort study, 51 HBsAg positive patients were selected. Five participants did not consent to HDV testing. The presence of anti-HDV IgG was checked in 46 patients (13 chronic hepatitis B and 33 inactive chronic hepatitis B) using enzyme-linked immunosorbent assay (ELISA) kit. The serum level of liver enzymes was measured and a questionnaire about risk factors was completed. Results: In this study, the mean age of HBsAg positive patients was 50.06 (SD 9.14) years and 41.3% were female. Only one out of 46 patients was positive for HDV infection. Thus, the prevalence of HDV infection among hepatitis B virus surface antigen (HBsAg) positive patients was 2.17% (95% CI: 0.1-11.5). The positive anti-HDV patient was in the inactive chronic hepatitis B state and she had a history of hospitalization and dental procedures. Conclusion: The results showed that the prevalence of HDV infection in HBsAg positive patients was 2.1% that was lower than the reported prevalence in many other regions of Iran. Health policymakers and healthcare providers should design coherent and orderly epidemiological studies for planning and monitoring HDV infection.
format Online
Article
Text
id pubmed-7036205
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Tabriz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-70362052020-02-26 Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study Pouri, Ali Asghar Ghojazadeh, Morteza Baiaz, Babak Hamzavi, Fatemeh Soghra Pourasghari, Behrouz Somi, Mohammad Hossein Health Promot Perspect Original Article Background: Hepatitis D virus (HDV) is a defective RNA pathogen that requires the presence of the hepatitis B virus (HBV) for infection. Middle East countries are endemic areas for HDV infection. So, it is important to estimate the prevalence of HDV in these countries. This study aimed to estimate the prevalence of HDV in HBsAg positive patients participated in Azar cohort study, North-west of Iran. Methods: In this cross-sectional study, out of 4949 participants of the Azar cohort study, 51 HBsAg positive patients were selected. Five participants did not consent to HDV testing. The presence of anti-HDV IgG was checked in 46 patients (13 chronic hepatitis B and 33 inactive chronic hepatitis B) using enzyme-linked immunosorbent assay (ELISA) kit. The serum level of liver enzymes was measured and a questionnaire about risk factors was completed. Results: In this study, the mean age of HBsAg positive patients was 50.06 (SD 9.14) years and 41.3% were female. Only one out of 46 patients was positive for HDV infection. Thus, the prevalence of HDV infection among hepatitis B virus surface antigen (HBsAg) positive patients was 2.17% (95% CI: 0.1-11.5). The positive anti-HDV patient was in the inactive chronic hepatitis B state and she had a history of hospitalization and dental procedures. Conclusion: The results showed that the prevalence of HDV infection in HBsAg positive patients was 2.1% that was lower than the reported prevalence in many other regions of Iran. Health policymakers and healthcare providers should design coherent and orderly epidemiological studies for planning and monitoring HDV infection. Tabriz University of Medical Sciences 2020-01-28 /pmc/articles/PMC7036205/ /pubmed/32104655 http://dx.doi.org/10.15171/hpp.2020.07 Text en © 2020 The Author(s). http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pouri, Ali Asghar
Ghojazadeh, Morteza
Baiaz, Babak
Hamzavi, Fatemeh Soghra
Pourasghari, Behrouz
Somi, Mohammad Hossein
Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title_full Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title_fullStr Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title_full_unstemmed Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title_short Prevalence of hepatitis D virus among HBsAg-positive individuals, 2015-2016: Azar cohort study
title_sort prevalence of hepatitis d virus among hbsag-positive individuals, 2015-2016: azar cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036205/
https://www.ncbi.nlm.nih.gov/pubmed/32104655
http://dx.doi.org/10.15171/hpp.2020.07
work_keys_str_mv AT pourialiasghar prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy
AT ghojazadehmorteza prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy
AT baiazbabak prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy
AT hamzavifatemehsoghra prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy
AT pourasgharibehrouz prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy
AT somimohammadhossein prevalenceofhepatitisdvirusamonghbsagpositiveindividuals20152016azarcohortstudy