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Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment
Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036313/ https://www.ncbi.nlm.nih.gov/pubmed/31650704 http://dx.doi.org/10.1002/vms3.201 |
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author | Tamlin, Vanessa S. Bottema, Cynthia D. K. Peaston, Anne E. |
author_facet | Tamlin, Vanessa S. Bottema, Cynthia D. K. Peaston, Anne E. |
author_sort | Tamlin, Vanessa S. |
collection | PubMed |
description | Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain KIT mutations are associated with more malignant and lethal disease. In contrast, KIT mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. KIT genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within KIT are classified as either regulatory‐type or enzymatic pocket‐type mutations according to their location within the KIT Proto‐Oncogene. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour KIT mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of KIT in the canine and feline forms in comparison to human mast cell neoplasia. |
format | Online Article Text |
id | pubmed-7036313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70363132020-02-26 Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment Tamlin, Vanessa S. Bottema, Cynthia D. K. Peaston, Anne E. Vet Med Sci Review Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the KIT Proto‐Oncogene Receptor Tyrosine Kinase (KIT) gene are common molecular abnormalities involved in mast cell tumorigenesis. KIT mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain KIT mutations are associated with more malignant and lethal disease. In contrast, KIT mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. KIT genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within KIT are classified as either regulatory‐type or enzymatic pocket‐type mutations according to their location within the KIT Proto‐Oncogene. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour KIT mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of KIT in the canine and feline forms in comparison to human mast cell neoplasia. John Wiley and Sons Inc. 2019-10-24 /pmc/articles/PMC7036313/ /pubmed/31650704 http://dx.doi.org/10.1002/vms3.201 Text en © 2019 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Tamlin, Vanessa S. Bottema, Cynthia D. K. Peaston, Anne E. Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title | Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title_full | Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title_fullStr | Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title_full_unstemmed | Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title_short | Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment |
title_sort | comparative aspects of mast cell neoplasia in animals and the role of kit in prognosis and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036313/ https://www.ncbi.nlm.nih.gov/pubmed/31650704 http://dx.doi.org/10.1002/vms3.201 |
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