MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer

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We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS mutant lung adenocarcinoma. Nevertheless, the evident toxicity restricts the use of wild-type (WT)-CVB3 for cancer therapy. The current study aims to engineer the CVB3 to decrease its toxicity and to extend...

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Detalles Bibliográficos
Autores principales: Liu, Huitao, Xue, Yuan Chao, Deng, Haoyu, Mohamud, Yasir, Ng, Chen Seng, Chu, Axel, Lim, Chinten James, Lockwood, William W., Jia, William W.G., Luo, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036525/
https://www.ncbi.nlm.nih.gov/pubmed/32123721
http://dx.doi.org/10.1016/j.omto.2020.01.002
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