Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report

Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. A...

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Autores principales: Mohamed, Shehab F., Helmi, Feryal, El-Akiki, Susanna, El Omri, Halima, Nashwan, Abdulqadir, Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036560/
https://www.ncbi.nlm.nih.gov/pubmed/32110210
http://dx.doi.org/10.1159/000504929
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author Mohamed, Shehab F.
Helmi, Feryal
El-Akiki, Susanna
El Omri, Halima
Nashwan, Abdulqadir
Yassin, Mohamed A.
author_facet Mohamed, Shehab F.
Helmi, Feryal
El-Akiki, Susanna
El Omri, Halima
Nashwan, Abdulqadir
Yassin, Mohamed A.
author_sort Mohamed, Shehab F.
collection PubMed
description Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. Although the association of both cancers (HCL and papillary thyroid cancer) with BRAF mutation is well established in the literature, as far as we know it has not been reported before in the same patient. Here we report 48-year-old male diagnosed with HCL and papillary thyroid cancer and who is BRAF positive in both diagnostic tissues.
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spelling pubmed-70365602020-02-27 Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report Mohamed, Shehab F. Helmi, Feryal El-Akiki, Susanna El Omri, Halima Nashwan, Abdulqadir Yassin, Mohamed A. Case Rep Oncol Case Report Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. Although the association of both cancers (HCL and papillary thyroid cancer) with BRAF mutation is well established in the literature, as far as we know it has not been reported before in the same patient. Here we report 48-year-old male diagnosed with HCL and papillary thyroid cancer and who is BRAF positive in both diagnostic tissues. S. Karger AG 2019-12-17 /pmc/articles/PMC7036560/ /pubmed/32110210 http://dx.doi.org/10.1159/000504929 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Mohamed, Shehab F.
Helmi, Feryal
El-Akiki, Susanna
El Omri, Halima
Nashwan, Abdulqadir
Yassin, Mohamed A.
Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title_full Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title_fullStr Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title_full_unstemmed Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title_short Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report
title_sort concomitant braf mutation in hairy cell leukemia and papillary thyroid cancer: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036560/
https://www.ncbi.nlm.nih.gov/pubmed/32110210
http://dx.doi.org/10.1159/000504929
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