Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability

Native state aggregation is an important concern in the development of therapeutic antibodies. Enhanced knowledge of mAb native state aggregation mechanisms would permit sequence-based selection and design of therapeutic mAbs with improved developability. We investigated how electrostatic interactio...

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Detalles Bibliográficos
Autores principales: Heads, James T, Lamb, Richard, Kelm, Sebastian, Adams, Ralph, Elliott, Peter, Tyson, Kerry, Topia, Sarfaraj, West, Shauna, Nan, Ruodan, Turner, Alison, Lawson, Alastair D G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036597/
https://www.ncbi.nlm.nih.gov/pubmed/31868219
http://dx.doi.org/10.1093/protein/gzz046

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