Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

OBJECTIVE: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we discovered an unexpected weight loss phenotype. The o...

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Detalles Bibliográficos
Autores principales: McCabe, Kristin M., Hsieh, Joanne, Thomas, David G., Molusky, Matthew M., Tascau, Liana, Feranil, Jun B., Qiang, Li, Ferrante, Anthony W., Tall, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036698/
https://www.ncbi.nlm.nih.gov/pubmed/32180554
http://dx.doi.org/10.1016/j.molmet.2020.01.010

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