Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR overexpression in hepatocytes. PB-miRs encoding six differ...

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Detalles Bibliográficos
Autores principales: Tipanee, Jaitip, Di Matteo, Mario, Tulalamba, Warut, Samara-Kuko, Ermira, Keirsse, Jiri, Van Ginderachter, Jo A., Chuah, Marinee Khim, VandenDriessche, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036702/
https://www.ncbi.nlm.nih.gov/pubmed/32160703
http://dx.doi.org/10.1016/j.omtn.2020.01.015

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