Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo

The efficient delivery of antisense oligonucleotides (ASOs) to the targeted cells and organs remains a challenge, in particular, in vivo. Here, we investigated the ability of a library of biodegradable lipid nanoparticles (LNPs) in delivering ASO to both cultured human cells and animal models. We fi...

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Detalles Bibliográficos
Autores principales: Yang, Liu, Ma, Feihe, Liu, Fang, Chen, Jinjin, Zhao, Xuewei, Xu, Qiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036716/
https://www.ncbi.nlm.nih.gov/pubmed/32160706
http://dx.doi.org/10.1016/j.omtn.2020.01.018

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