Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine

Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their s...

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Detalles Bibliográficos
Autores principales: Sun, Peng, Cao, Dong-Hua, Xiao, Yi-Dian, Zhang, Zong-Yi, Wang, Jia-Nan, Shi, Xiao-Cui, Xiao, Chun-Fen, Hu, Hua-Bin, Xu, You-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036900/
https://www.ncbi.nlm.nih.gov/pubmed/31991808
http://dx.doi.org/10.3390/molecules25030529
Descripción
Sumario:Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.

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