Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine

Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their s...

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Autores principales: Sun, Peng, Cao, Dong-Hua, Xiao, Yi-Dian, Zhang, Zong-Yi, Wang, Jia-Nan, Shi, Xiao-Cui, Xiao, Chun-Fen, Hu, Hua-Bin, Xu, You-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036900/
https://www.ncbi.nlm.nih.gov/pubmed/31991808
http://dx.doi.org/10.3390/molecules25030529
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author Sun, Peng
Cao, Dong-Hua
Xiao, Yi-Dian
Zhang, Zong-Yi
Wang, Jia-Nan
Shi, Xiao-Cui
Xiao, Chun-Fen
Hu, Hua-Bin
Xu, You-Kai
author_facet Sun, Peng
Cao, Dong-Hua
Xiao, Yi-Dian
Zhang, Zong-Yi
Wang, Jia-Nan
Shi, Xiao-Cui
Xiao, Chun-Fen
Hu, Hua-Bin
Xu, You-Kai
author_sort Sun, Peng
collection PubMed
description Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.
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spelling pubmed-70369002020-03-11 Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine Sun, Peng Cao, Dong-Hua Xiao, Yi-Dian Zhang, Zong-Yi Wang, Jia-Nan Shi, Xiao-Cui Xiao, Chun-Fen Hu, Hua-Bin Xu, You-Kai Molecules Article Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production. MDPI 2020-01-25 /pmc/articles/PMC7036900/ /pubmed/31991808 http://dx.doi.org/10.3390/molecules25030529 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Peng
Cao, Dong-Hua
Xiao, Yi-Dian
Zhang, Zong-Yi
Wang, Jia-Nan
Shi, Xiao-Cui
Xiao, Chun-Fen
Hu, Hua-Bin
Xu, You-Kai
Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title_full Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title_fullStr Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title_full_unstemmed Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title_short Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine
title_sort aspidoptoids a–d: four new diterpenoids from aspidopterys obcordata vine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036900/
https://www.ncbi.nlm.nih.gov/pubmed/31991808
http://dx.doi.org/10.3390/molecules25030529
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