Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor

Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation a...

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Autores principales: Xu, Wen-Wen, Wang, Le, Mao, Ting, Gu, Jiwei, Li, Xiao-Fei, He, Chun-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036948/
https://www.ncbi.nlm.nih.gov/pubmed/31991642
http://dx.doi.org/10.3390/molecules25030508
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author Xu, Wen-Wen
Wang, Le
Mao, Ting
Gu, Jiwei
Li, Xiao-Fei
He, Chun-Yang
author_facet Xu, Wen-Wen
Wang, Le
Mao, Ting
Gu, Jiwei
Li, Xiao-Fei
He, Chun-Yang
author_sort Xu, Wen-Wen
collection PubMed
description Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences.
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spelling pubmed-70369482020-03-11 Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor Xu, Wen-Wen Wang, Le Mao, Ting Gu, Jiwei Li, Xiao-Fei He, Chun-Yang Molecules Communication Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences. MDPI 2020-01-24 /pmc/articles/PMC7036948/ /pubmed/31991642 http://dx.doi.org/10.3390/molecules25030508 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Xu, Wen-Wen
Wang, Le
Mao, Ting
Gu, Jiwei
Li, Xiao-Fei
He, Chun-Yang
Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title_full Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title_fullStr Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title_full_unstemmed Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title_short Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
title_sort visible-light promoted atom transfer radical addition−elimination (atre) reaction for the synthesis of fluoroalkylated alkenes using dma as electron-donor
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036948/
https://www.ncbi.nlm.nih.gov/pubmed/31991642
http://dx.doi.org/10.3390/molecules25030508
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