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Disparate Phenotypes Resulting from Mutations of a Single Histidine in Switch II of Geobacillus stearothermophilus Translation Initiation Factor IF2

The conserved Histidine 301 in switch II of Geobacillus stearothermophilus IF2 G2 domain was substituted with Ser, Gln, Arg, Leu and Tyr to generate mutants displaying different phenotypes. Overexpression of IF2H301S, IF2H301L and IF2H301Y in cells expressing wtIF2, unlike IF2H301Q and IF2H301R, cau...

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Detalles Bibliográficos
Autores principales:	Tomsic, Jerneja, Smorlesi, Arianna, Caserta, Enrico, Giuliodori, Anna Maria, Pon, Cynthia L., Gualerzi, Claudio O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037019/ https://www.ncbi.nlm.nih.gov/pubmed/31979156 http://dx.doi.org/10.3390/ijms21030735

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