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Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

During inflammation, activated leukocytes release cytotoxic mediators that compromise blood–brain barrier (BBB) function. Under inflammatory conditions, myeloperoxidase (MPO) is critically involved in inflicting BBB damage. We used genetic and pharmacological approaches to investigate whether MPO in...

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Detalles Bibliográficos
Autores principales:	Goeritzer, Madeleine, Bernhart, Eva, Plastira, Ioanna, Reicher, Helga, Leopold, Christina, Eichmann, Thomas O., Rechberger, Gerald, Madreiter-Sokolowski, Corina T., Prasch, Jürgen, Eller, Philipp, Graier, Wolfgang F., Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037060/ https://www.ncbi.nlm.nih.gov/pubmed/32050431 http://dx.doi.org/10.3390/ijms21031143

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