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Spider Silk for Tissue Engineering Applications

Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since n...

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Detalles Bibliográficos
Autores principales: Salehi, Sahar, Koeck, Kim, Scheibel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037138/
https://www.ncbi.nlm.nih.gov/pubmed/32046280
http://dx.doi.org/10.3390/molecules25030737
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author Salehi, Sahar
Koeck, Kim
Scheibel, Thomas
author_facet Salehi, Sahar
Koeck, Kim
Scheibel, Thomas
author_sort Salehi, Sahar
collection PubMed
description Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since natural production using spiders is limited due to problems with farming spiders, recombinant production of spider silk proteins seems to be the best way to produce material in sufficient quantities. The availability of recombinantly produced spider silk proteins, as well as their good processability has opened the path towards modern biomedical applications. Here, we highlight the research on spider silk-based materials in the field of tissue engineering and summarize various two-dimensional (2D) and three-dimensional (3D) scaffolds made of spider silk. Finally, different applications of spider silk-based materials are reviewed in the field of tissue engineering in vitro and in vivo.
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spelling pubmed-70371382020-03-11 Spider Silk for Tissue Engineering Applications Salehi, Sahar Koeck, Kim Scheibel, Thomas Molecules Review Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since natural production using spiders is limited due to problems with farming spiders, recombinant production of spider silk proteins seems to be the best way to produce material in sufficient quantities. The availability of recombinantly produced spider silk proteins, as well as their good processability has opened the path towards modern biomedical applications. Here, we highlight the research on spider silk-based materials in the field of tissue engineering and summarize various two-dimensional (2D) and three-dimensional (3D) scaffolds made of spider silk. Finally, different applications of spider silk-based materials are reviewed in the field of tissue engineering in vitro and in vivo. MDPI 2020-02-08 /pmc/articles/PMC7037138/ /pubmed/32046280 http://dx.doi.org/10.3390/molecules25030737 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salehi, Sahar
Koeck, Kim
Scheibel, Thomas
Spider Silk for Tissue Engineering Applications
title Spider Silk for Tissue Engineering Applications
title_full Spider Silk for Tissue Engineering Applications
title_fullStr Spider Silk for Tissue Engineering Applications
title_full_unstemmed Spider Silk for Tissue Engineering Applications
title_short Spider Silk for Tissue Engineering Applications
title_sort spider silk for tissue engineering applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037138/
https://www.ncbi.nlm.nih.gov/pubmed/32046280
http://dx.doi.org/10.3390/molecules25030737
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