The Endocannabinoid System: A Target for Cancer Treatment

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However...

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Autores principales: Laezza, Chiara, Pagano, Cristina, Navarra, Giovanna, Pastorino, Olga, Proto, Maria Chiara, Fiore, Donatella, Piscopo, Chiara, Gazzerro, Patrizia, Bifulco, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037210/
https://www.ncbi.nlm.nih.gov/pubmed/31979368
http://dx.doi.org/10.3390/ijms21030747
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author Laezza, Chiara
Pagano, Cristina
Navarra, Giovanna
Pastorino, Olga
Proto, Maria Chiara
Fiore, Donatella
Piscopo, Chiara
Gazzerro, Patrizia
Bifulco, Maurizio
author_facet Laezza, Chiara
Pagano, Cristina
Navarra, Giovanna
Pastorino, Olga
Proto, Maria Chiara
Fiore, Donatella
Piscopo, Chiara
Gazzerro, Patrizia
Bifulco, Maurizio
author_sort Laezza, Chiara
collection PubMed
description In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
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spelling pubmed-70372102020-03-11 The Endocannabinoid System: A Target for Cancer Treatment Laezza, Chiara Pagano, Cristina Navarra, Giovanna Pastorino, Olga Proto, Maria Chiara Fiore, Donatella Piscopo, Chiara Gazzerro, Patrizia Bifulco, Maurizio Int J Mol Sci Review In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression. MDPI 2020-01-23 /pmc/articles/PMC7037210/ /pubmed/31979368 http://dx.doi.org/10.3390/ijms21030747 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Laezza, Chiara
Pagano, Cristina
Navarra, Giovanna
Pastorino, Olga
Proto, Maria Chiara
Fiore, Donatella
Piscopo, Chiara
Gazzerro, Patrizia
Bifulco, Maurizio
The Endocannabinoid System: A Target for Cancer Treatment
title The Endocannabinoid System: A Target for Cancer Treatment
title_full The Endocannabinoid System: A Target for Cancer Treatment
title_fullStr The Endocannabinoid System: A Target for Cancer Treatment
title_full_unstemmed The Endocannabinoid System: A Target for Cancer Treatment
title_short The Endocannabinoid System: A Target for Cancer Treatment
title_sort endocannabinoid system: a target for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037210/
https://www.ncbi.nlm.nih.gov/pubmed/31979368
http://dx.doi.org/10.3390/ijms21030747
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