Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens

A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producen...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Mioko, Satake, Masayuki, Zhang, Bo-Tao, Xiao, Yue-Yun, Fukuoka, Masayuki, Uchida, Hajime, Nagai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037229/
https://www.ncbi.nlm.nih.gov/pubmed/31978978
http://dx.doi.org/10.3390/molecules25030457
Descripción
Sumario:A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.

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