Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens

A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producen...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Mioko, Satake, Masayuki, Zhang, Bo-Tao, Xiao, Yue-Yun, Fukuoka, Masayuki, Uchida, Hajime, Nagai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037229/
https://www.ncbi.nlm.nih.gov/pubmed/31978978
http://dx.doi.org/10.3390/molecules25030457
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author Kawaguchi, Mioko
Satake, Masayuki
Zhang, Bo-Tao
Xiao, Yue-Yun
Fukuoka, Masayuki
Uchida, Hajime
Nagai, Hiroshi
author_facet Kawaguchi, Mioko
Satake, Masayuki
Zhang, Bo-Tao
Xiao, Yue-Yun
Fukuoka, Masayuki
Uchida, Hajime
Nagai, Hiroshi
author_sort Kawaguchi, Mioko
collection PubMed
description A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.
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spelling pubmed-70372292020-03-11 Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens Kawaguchi, Mioko Satake, Masayuki Zhang, Bo-Tao Xiao, Yue-Yun Fukuoka, Masayuki Uchida, Hajime Nagai, Hiroshi Molecules Communication A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities. MDPI 2020-01-22 /pmc/articles/PMC7037229/ /pubmed/31978978 http://dx.doi.org/10.3390/molecules25030457 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kawaguchi, Mioko
Satake, Masayuki
Zhang, Bo-Tao
Xiao, Yue-Yun
Fukuoka, Masayuki
Uchida, Hajime
Nagai, Hiroshi
Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title_full Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title_fullStr Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title_full_unstemmed Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title_short Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
title_sort neo-aplysiatoxin a isolated from okinawan cyanobacterium moorea producens
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037229/
https://www.ncbi.nlm.nih.gov/pubmed/31978978
http://dx.doi.org/10.3390/molecules25030457
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