Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

Blood–brain barrier (BBB) dysfunction has been suggested to play an important role in epilepsy. However, the mechanism mediating the transition from cerebrovascular damage to epilepsy remains unknown. Here, we report that endothelial cyclin-dependent kinase 5 (CDK5) is a central regulator of neurona...

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Detalles Bibliográficos
Autores principales: Liu, Xiu-xiu, Yang, Lin, Shao, Ling-xiao, He, Yang, Wu, Gang, Bao, Yu-huan, Lu, Nan-nan, Gong, Dong-mei, Lu, Ya-ping, Cui, Tian-tian, Sun, Ning-he, Chen, Dan-yang, Shi, Wei-xing, Fukunaga, Kohji, Chen, Hong-shan, Chen, Zhong, Han, Feng, Lu, Ying-mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037235/
https://www.ncbi.nlm.nih.gov/pubmed/31699822
http://dx.doi.org/10.1084/jem.20180992

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