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Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion
Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both fro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037241/ https://www.ncbi.nlm.nih.gov/pubmed/31821443 http://dx.doi.org/10.1084/jem.20190295 |
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author | Broggi, Achille Granucci, Francesca Zanoni, Ivan |
author_facet | Broggi, Achille Granucci, Francesca Zanoni, Ivan |
author_sort | Broggi, Achille |
collection | PubMed |
description | Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges. |
format | Online Article Text |
id | pubmed-7037241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70372412020-07-06 Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion Broggi, Achille Granucci, Francesca Zanoni, Ivan J Exp Med Reviews Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges. Rockefeller University Press 2019-12-05 /pmc/articles/PMC7037241/ /pubmed/31821443 http://dx.doi.org/10.1084/jem.20190295 Text en © 2019 Broggi et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Broggi, Achille Granucci, Francesca Zanoni, Ivan Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title | Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title_full | Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title_fullStr | Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title_full_unstemmed | Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title_short | Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion |
title_sort | type iii interferons: balancing tissue tolerance and resistance to pathogen invasion |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037241/ https://www.ncbi.nlm.nih.gov/pubmed/31821443 http://dx.doi.org/10.1084/jem.20190295 |
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