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The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review

The embryo of an oocyte donation (OD) pregnancy is completely allogeneic to the mother, which leads to a more serious challenge for the maternal immune system to tolerize the fetus. It is thought that macrophages are essential in maintaining a healthy pregnancy, by acting in immunomodulation and spi...

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Autores principales: Tian, Xuezi, Eikmans, Michael, van der Hoorn, Marie-Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037275/
https://www.ncbi.nlm.nih.gov/pubmed/32023856
http://dx.doi.org/10.3390/ijms21030939
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author Tian, Xuezi
Eikmans, Michael
van der Hoorn, Marie-Louise
author_facet Tian, Xuezi
Eikmans, Michael
van der Hoorn, Marie-Louise
author_sort Tian, Xuezi
collection PubMed
description The embryo of an oocyte donation (OD) pregnancy is completely allogeneic to the mother, which leads to a more serious challenge for the maternal immune system to tolerize the fetus. It is thought that macrophages are essential in maintaining a healthy pregnancy, by acting in immunomodulation and spiral arterial remodeling. OD pregnancies represent an interesting model to study complex immunologic interactions between the fetus and the pregnant woman since the embryo is totally allogeneic compared to the mother. Here, we describe a narrative review on the role of macrophages and pregnancy and a systematic review was performed on the role of macrophages in OD pregnancies. Searches were made in different databases and the titles and abstracts were evaluated by three independent authors. In total, four articles were included on OD pregnancies and macrophages. Among these articles, some findings are conflicting between studies, indicating that more research is needed in this area. From current research, we could identify that there are multiple subtypes of macrophages, having diverse biological effects, and that the ratio between subtypes is altered during gestation and in aberrant pregnancy. The study of macrophages’ phenotypes and their functions in OD pregnancies might be beneficial to better understand the maternal-fetal tolerance system.
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spelling pubmed-70372752020-03-11 The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review Tian, Xuezi Eikmans, Michael van der Hoorn, Marie-Louise Int J Mol Sci Review The embryo of an oocyte donation (OD) pregnancy is completely allogeneic to the mother, which leads to a more serious challenge for the maternal immune system to tolerize the fetus. It is thought that macrophages are essential in maintaining a healthy pregnancy, by acting in immunomodulation and spiral arterial remodeling. OD pregnancies represent an interesting model to study complex immunologic interactions between the fetus and the pregnant woman since the embryo is totally allogeneic compared to the mother. Here, we describe a narrative review on the role of macrophages and pregnancy and a systematic review was performed on the role of macrophages in OD pregnancies. Searches were made in different databases and the titles and abstracts were evaluated by three independent authors. In total, four articles were included on OD pregnancies and macrophages. Among these articles, some findings are conflicting between studies, indicating that more research is needed in this area. From current research, we could identify that there are multiple subtypes of macrophages, having diverse biological effects, and that the ratio between subtypes is altered during gestation and in aberrant pregnancy. The study of macrophages’ phenotypes and their functions in OD pregnancies might be beneficial to better understand the maternal-fetal tolerance system. MDPI 2020-01-31 /pmc/articles/PMC7037275/ /pubmed/32023856 http://dx.doi.org/10.3390/ijms21030939 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tian, Xuezi
Eikmans, Michael
van der Hoorn, Marie-Louise
The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title_full The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title_fullStr The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title_full_unstemmed The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title_short The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review
title_sort role of macrophages in oocyte donation pregnancy: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037275/
https://www.ncbi.nlm.nih.gov/pubmed/32023856
http://dx.doi.org/10.3390/ijms21030939
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