Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl...

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Detalles Bibliográficos
Autores principales: Meng, Chenkai, Niu, Haolin, Ning, Juehan, Wu, Wengang, Yi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037277/
https://www.ncbi.nlm.nih.gov/pubmed/32019185
http://dx.doi.org/10.3390/molecules25030602
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author Meng, Chenkai
Niu, Haolin
Ning, Juehan
Wu, Wengang
Yi, Jun
author_facet Meng, Chenkai
Niu, Haolin
Ning, Juehan
Wu, Wengang
Yi, Jun
author_sort Meng, Chenkai
collection PubMed
description An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.
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spelling pubmed-70372772020-03-11 Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process Meng, Chenkai Niu, Haolin Ning, Juehan Wu, Wengang Yi, Jun Molecules Communication An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group. MDPI 2020-01-30 /pmc/articles/PMC7037277/ /pubmed/32019185 http://dx.doi.org/10.3390/molecules25030602 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Meng, Chenkai
Niu, Haolin
Ning, Juehan
Wu, Wengang
Yi, Jun
Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_full Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_fullStr Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_full_unstemmed Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_short Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_sort nickel-catalyzed removal of alkene protecting group of phenols, alcohols via chain walking process
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037277/
https://www.ncbi.nlm.nih.gov/pubmed/32019185
http://dx.doi.org/10.3390/molecules25030602
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AT ningjuehan nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess
AT wuwengang nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess
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