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Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones
A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037326/ https://www.ncbi.nlm.nih.gov/pubmed/32028657 http://dx.doi.org/10.3390/molecules25030648 |
| _version_ | 1783500401454088192 |
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| author | Zhou, Yu-Hao Zhang, Yu-Zu Wu, Zhu-Lian Cai, Tian Wen, Wei Guo, Qi-Xiang |
| author_facet | Zhou, Yu-Hao Zhang, Yu-Zu Wu, Zhu-Lian Cai, Tian Wen, Wei Guo, Qi-Xiang |
| author_sort | Zhou, Yu-Hao |
| collection | PubMed |
| description | A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities. |
| format | Online Article Text |
| id | pubmed-7037326 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70373262020-03-11 Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones Zhou, Yu-Hao Zhang, Yu-Zu Wu, Zhu-Lian Cai, Tian Wen, Wei Guo, Qi-Xiang Molecules Article A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities. MDPI 2020-02-03 /pmc/articles/PMC7037326/ /pubmed/32028657 http://dx.doi.org/10.3390/molecules25030648 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Zhou, Yu-Hao Zhang, Yu-Zu Wu, Zhu-Lian Cai, Tian Wen, Wei Guo, Qi-Xiang Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title | Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title_full | Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title_fullStr | Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title_full_unstemmed | Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title_short | Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones |
| title_sort | organocatalytic asymmetric aldol reaction of arylglyoxals and hydroxyacetone: enantioselective synthesis of 2,3-dihydroxy-1,4-diones |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037326/ https://www.ncbi.nlm.nih.gov/pubmed/32028657 http://dx.doi.org/10.3390/molecules25030648 |
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