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Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones

A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.

Detalles Bibliográficos
Autores principales:	Zhou, Yu-Hao, Zhang, Yu-Zu, Wu, Zhu-Lian, Cai, Tian, Wen, Wei, Guo, Qi-Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037326/ https://www.ncbi.nlm.nih.gov/pubmed/32028657 http://dx.doi.org/10.3390/molecules25030648

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