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Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor

Accumulation of β-amyloid (Aβ) in the brain has been implicated in the pathology of Alzheimer’s disease (AD). Aβ is produced from the Aβ precursor protein (APP) through the amyloidogenic pathway by β-, and γ-secretase. Alternatively, APP can be cleaved by α-, and γ-secretase, precluding the producti...

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Detalles Bibliográficos
Autores principales:	Chun, Yoon Sun, Cho, Yoon Young, Kwon, Oh Hoon, Zhao, Dong, Yang, Hyun Ok, Chung, Sungkwon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037359/ https://www.ncbi.nlm.nih.gov/pubmed/32028607 http://dx.doi.org/10.3390/molecules25030646

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