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Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review
Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037405/ https://www.ncbi.nlm.nih.gov/pubmed/32041140 http://dx.doi.org/10.3390/molecules25030689 |
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author | Moballegh Nasery, Mahshid Abadi, Banafshe Poormoghadam, Delaram Zarrabi, Ali Keyhanvar, Peyman Khanbabaei, Hashem Ashrafizadeh, Milad Mohammadinejad, Reza Tavakol, Shima Sethi, Gautam |
author_facet | Moballegh Nasery, Mahshid Abadi, Banafshe Poormoghadam, Delaram Zarrabi, Ali Keyhanvar, Peyman Khanbabaei, Hashem Ashrafizadeh, Milad Mohammadinejad, Reza Tavakol, Shima Sethi, Gautam |
author_sort | Moballegh Nasery, Mahshid |
collection | PubMed |
description | Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associated with their solubility, bioavailability, and bio-degradability. In the present review, we focus on curcumin, an important and widely used polyphenol, with diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic, anti-viral, etc. Notwithstanding, it also exhibits poor solubility and bioavailability that may compromise its clinical application to a great extent. Therefore, the manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy. Among different types of nanocarriers, biological and biopolymer carriers have attracted a significant attention due to their pleiotropic features. Thus, in the present review, the potential protective and therapeutic applications of curcumin, as well as different types of bio-nanocarriers, which can be used to deliver curcumin effectively to the different target sites will be discussed. |
format | Online Article Text |
id | pubmed-7037405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70374052020-03-11 Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review Moballegh Nasery, Mahshid Abadi, Banafshe Poormoghadam, Delaram Zarrabi, Ali Keyhanvar, Peyman Khanbabaei, Hashem Ashrafizadeh, Milad Mohammadinejad, Reza Tavakol, Shima Sethi, Gautam Molecules Review Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associated with their solubility, bioavailability, and bio-degradability. In the present review, we focus on curcumin, an important and widely used polyphenol, with diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic, anti-viral, etc. Notwithstanding, it also exhibits poor solubility and bioavailability that may compromise its clinical application to a great extent. Therefore, the manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy. Among different types of nanocarriers, biological and biopolymer carriers have attracted a significant attention due to their pleiotropic features. Thus, in the present review, the potential protective and therapeutic applications of curcumin, as well as different types of bio-nanocarriers, which can be used to deliver curcumin effectively to the different target sites will be discussed. MDPI 2020-02-06 /pmc/articles/PMC7037405/ /pubmed/32041140 http://dx.doi.org/10.3390/molecules25030689 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moballegh Nasery, Mahshid Abadi, Banafshe Poormoghadam, Delaram Zarrabi, Ali Keyhanvar, Peyman Khanbabaei, Hashem Ashrafizadeh, Milad Mohammadinejad, Reza Tavakol, Shima Sethi, Gautam Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title | Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title_full | Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title_fullStr | Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title_full_unstemmed | Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title_short | Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review |
title_sort | curcumin delivery mediated by bio-based nanoparticles: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037405/ https://www.ncbi.nlm.nih.gov/pubmed/32041140 http://dx.doi.org/10.3390/molecules25030689 |
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