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Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase

A newly recognized action of organophosphates (OP) is the ability to crosslink proteins through an isopeptide bond. The first step in the mechanism is covalent addition of the OP to the side chain of lysine. This activates OP-lysine for reaction with a nearby glutamic or aspartic acid to make a gamm...

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Detalles Bibliográficos
Autores principales:	Biberoglu, Kevser, Tacal, Ozden, Schopfer, Lawrence M., Lockridge, Oksana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037448/ https://www.ncbi.nlm.nih.gov/pubmed/31991818 http://dx.doi.org/10.3390/molecules25030533

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