Comparison of Eight Technologies to Determine Genotype at the UGT1A1 (TA)(n) Repeat Polymorphism: Potential Clinical Consequences of Genotyping Errors?

To ensure accuracy of UGT1A1 (TA)(n) (rs3064744) genotyping for use in pharmacogenomics-based irinotecan dosing, we tested the concordance of several commonly used genotyping technologies. Heuristic genotype groupings and principal component analysis demonstrated concordance for Illumina sequencing,...

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Detalles Bibliográficos
Autores principales: Sissung, Tristan M., Barbier, Roberto H., Price, Douglas K., Plona, Teri M., Pike, Kristen M., Mellott, Stephanie D., Baugher, Ryan N., Whiteley, Gordon R., Soppet, Daniel R., Venzon, David, Berman, Arlene, Rajan, Arun, Giaccone, Giuseppe, Meltzer, Paul, Figg, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037496/
https://www.ncbi.nlm.nih.gov/pubmed/32019188
http://dx.doi.org/10.3390/ijms21030896

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