Cargando…

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide. Interestingly, a significant number of patients have clinical and neuropathological features of both AD and PD, i.e., the presence of amyloid deposi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Köppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Hähnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Rübsamen, Maike, Morawski, Markus, von Hörsten, Stephan, Demuth, Hans-Ulrich, Roßner, Steffen, Schilling, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037551/ https://www.ncbi.nlm.nih.gov/pubmed/32013170 http://dx.doi.org/10.3390/molecules25030580

Ejemplares similares

Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2019)

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model
por: Bluhm, Alexandra, et al.
Publicado: (2022)

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2021)

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2011)

Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease
por: Morawski, Markus, et al.
Publicado: (2010)

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2015)

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology
por: Gnoth, Kathrin, et al.
Publicado: (2020)

Proteolytic α-Synuclein Cleavage in Health and Disease
por: Bluhm, Alexandra, et al.
Publicado: (2021)

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Höfling, Corinna, et al.
Publicado: (2019)

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2018)

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain
por: Heiland, Tina, et al.
Publicado: (2018)

QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
por: Yates, Sharon C., et al.
Publicado: (2019)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
por: Becker, Andreas, et al.
Publicado: (2013)

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
por: Barendrecht, Susan, et al.
Publicado: (2023)

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
por: Cynis, Holger, et al.
Publicado: (2011)

Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy
por: Mészáros, Lisa, et al.
Publicado: (2021)

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies
por: Höfling, Corinna, et al.
Publicado: (2016)

Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice
por: Ilse, Victoria, et al.
Publicado: (2022)

Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review
por: Klose, Jana, et al.
Publicado: (2022)

Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study
por: Frost, Jeffrey L., et al.
Publicado: (2012)

Atkins – the superior slimming diet?
por: Rössner, Stephan
Publicado: (2007)

Dysphagia caused by focal guttural pouch mycosis: mononeuropathy of the pharyngeal ramus of the vagal nerve in a 20-year-old pony mare
por: Eichentopf, Annemarie, et al.
Publicado: (2013)

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
por: Bayly-Jones, Charles, et al.
Publicado: (2022)

Peer teaching under pandemic conditions – options and challenges of online tutorials on practical skills
por: Dohle, Niklas Julian, et al.
Publicado: (2021)

Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency
por: Schmiedl, Andreas, et al.
Publicado: (2021)

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
por: Wirths, Oliver, et al.
Publicado: (2009)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Sorting Out the Role of α-Synuclein in Retromer-Mediated Endosomal Protein Sorting
por: Patel, Dhaval, et al.
Publicado: (2018)

Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease
por: Nguyen, Huu Phuc, et al.
Publicado: (2010)

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease
por: Helmschrodt, Christin, et al.
Publicado: (2017)

Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease
por: Rajasekaran, Santhanasabapathy, et al.
Publicado: (2021)

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
por: Anderson, Eric N., et al.
Publicado: (2020)

Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein
por: Albus, Alexandra, et al.
Publicado: (2018)

Attitude and treatment options in implant-supported prosthetics: A survey among a cohort of German dentists
por: Glücker, Carolin, et al.
Publicado: (2020)

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
por: Lloyd, Grace M., et al.
Publicado: (2023)

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models
por: Schulze-Krebs, Anja, et al.
Publicado: (2021)

Spermidine protects against α-synuclein neurotoxicity
por: Büttner, Sabrina, et al.
Publicado: (2014)

Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility
por: Gajendran, Nithya, et al.
Publicado: (2023)

The synucleins
por: George, Julia M
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_oss1l2rk5ndi582iq21hrksu3p