Discovery of novel and potent P2Y(14)R antagonists via structure-based virtual screening for the treatment of acute gouty arthritis

P2Y(14) nucleotide receptor is a Gi protein-coupled receptor, which is widely involved in physiological and pathologic events. Although several P2Y(14)R antagonists have been developed thus far, few have successfully been developed into a therapeutic drug. In this study, on the basis of two P2Y(14)R...

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Detalles Bibliográficos
Autores principales: Wang, Weiwei, Liu, Chunxiao, Li, Hanwen, Tian, Sheng, Liu, Yingxian, Wang, Nanxi, Yan, Duanyang, Li, Huanqiu, Hu, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037572/
https://www.ncbi.nlm.nih.gov/pubmed/32123586
http://dx.doi.org/10.1016/j.jare.2020.02.007

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