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Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain

Mammalian heart valves are soft tissue assemblies with multi-scale material properties. This is because they are constructs comprising both muscle and non-contractile extracellular matrix proteins (such as collagens and proteoglycans) and transition regions where one form of tissue structure becomes...

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Autores principales: Madhurapantula, Rama S., Krell, Gabriel, Morfin, Berenice, Roy, Rajarshi, Lister, Kevin, Orgel, Joseph P.R.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037596/
https://www.ncbi.nlm.nih.gov/pubmed/31991583
http://dx.doi.org/10.3390/ijms21030763
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author Madhurapantula, Rama S.
Krell, Gabriel
Morfin, Berenice
Roy, Rajarshi
Lister, Kevin
Orgel, Joseph P.R.O.
author_facet Madhurapantula, Rama S.
Krell, Gabriel
Morfin, Berenice
Roy, Rajarshi
Lister, Kevin
Orgel, Joseph P.R.O.
author_sort Madhurapantula, Rama S.
collection PubMed
description Mammalian heart valves are soft tissue assemblies with multi-scale material properties. This is because they are constructs comprising both muscle and non-contractile extracellular matrix proteins (such as collagens and proteoglycans) and transition regions where one form of tissue structure becomes another, significantly different form. The leaflets of the mitral and tricuspid valves are connected to chordae tendinae which, in turn, bind through papillary muscles to the cardiac wall of the ventricle. The transition regions between these tissue subsets are complex and diffuse. Their material composition and mechanical properties have not been previously described with both micro and nanoscopic data recorded simultaneously, as reported here. Annotating the mechanical characteristics of these tissue transitions will be of great value in developing novel implants, improving the state of the surgical simulators and advancing robot-assisted surgery. We present here developments in multi-scale methodology that produce data that can relate mechanical properties to molecular structure using scanning X-ray diffraction. We correlate these data to corresponding tissue level (macro and microscopic) stress and strain, with particular emphasis on the transition regions and present analyses to indicate points of possible failure in these tissues.
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spelling pubmed-70375962020-03-11 Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain Madhurapantula, Rama S. Krell, Gabriel Morfin, Berenice Roy, Rajarshi Lister, Kevin Orgel, Joseph P.R.O. Int J Mol Sci Article Mammalian heart valves are soft tissue assemblies with multi-scale material properties. This is because they are constructs comprising both muscle and non-contractile extracellular matrix proteins (such as collagens and proteoglycans) and transition regions where one form of tissue structure becomes another, significantly different form. The leaflets of the mitral and tricuspid valves are connected to chordae tendinae which, in turn, bind through papillary muscles to the cardiac wall of the ventricle. The transition regions between these tissue subsets are complex and diffuse. Their material composition and mechanical properties have not been previously described with both micro and nanoscopic data recorded simultaneously, as reported here. Annotating the mechanical characteristics of these tissue transitions will be of great value in developing novel implants, improving the state of the surgical simulators and advancing robot-assisted surgery. We present here developments in multi-scale methodology that produce data that can relate mechanical properties to molecular structure using scanning X-ray diffraction. We correlate these data to corresponding tissue level (macro and microscopic) stress and strain, with particular emphasis on the transition regions and present analyses to indicate points of possible failure in these tissues. MDPI 2020-01-24 /pmc/articles/PMC7037596/ /pubmed/31991583 http://dx.doi.org/10.3390/ijms21030763 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madhurapantula, Rama S.
Krell, Gabriel
Morfin, Berenice
Roy, Rajarshi
Lister, Kevin
Orgel, Joseph P.R.O.
Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title_full Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title_fullStr Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title_full_unstemmed Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title_short Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain
title_sort advanced methodology and preliminary measurements of molecular and mechanical properties of heart valves under dynamic strain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037596/
https://www.ncbi.nlm.nih.gov/pubmed/31991583
http://dx.doi.org/10.3390/ijms21030763
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