Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients

Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug monitoring. Germline mutations in cytochrome P450 isoforms 4 and 5 genes (CYP3A4/5) and the ATP-binding cassette B1 gene (ABCB1) may contribute to...

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Detalles Bibliográficos
Autores principales: Zhu, Jing, Patel, Tejendra, Miller, Jordan A., Torrice, Chad D., Aggarwal, Mehak, Sketch, Margaret R., Alexander, Maurice D., Armistead, Paul M., Coghill, James M., Grgic, Tatjana, Jamieson, Katarzyna J., Ptachcinski, Jonathan R., Riches, Marcie L., Serody, Jonathan S., Schmitz, John L., Shaw, J. Ryan, Shea, Thomas C., Suzuki, Oscar, Vincent, Benjamin G., Wood, William A., Rao, Kamakshi V., Wiltshire, Tim, Weimer, Eric T., Crona, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037631/
https://www.ncbi.nlm.nih.gov/pubmed/32013193
http://dx.doi.org/10.3390/ijms21030858

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