Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2′-Dibromo-2,4′,5′-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug

Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49-API), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduce by-products and achieve better impurity profiles. Mean...

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Detalles Bibliográficos
Autores principales: Feng, Xiu E, Cui, Ke Meng, Li, Qing Shan, Wu, Zi Cheng, Lei, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037700/
https://www.ncbi.nlm.nih.gov/pubmed/31979084
http://dx.doi.org/10.3390/molecules25030468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037700/
https://www.ncbi.nlm.nih.gov/pubmed/31979084
http://dx.doi.org/10.3390/molecules25030468

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