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Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epid...

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Autores principales: Sirufo, Maria Maddalena, Suppa, Mariano, Ginaldi, Lia, De Martinis, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037724/
https://www.ncbi.nlm.nih.gov/pubmed/31973226
http://dx.doi.org/10.3390/ijms21030712
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author Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
De Martinis, Massimo
author_facet Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
De Martinis, Massimo
author_sort Sirufo, Maria Maddalena
collection PubMed
description Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.
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spelling pubmed-70377242020-03-10 Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia De Martinis, Massimo Int J Mol Sci Review Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation. MDPI 2020-01-21 /pmc/articles/PMC7037724/ /pubmed/31973226 http://dx.doi.org/10.3390/ijms21030712 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
De Martinis, Massimo
Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title_full Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title_fullStr Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title_full_unstemmed Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title_short Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
title_sort does allergy break bones? osteoporosis and its connection to allergy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037724/
https://www.ncbi.nlm.nih.gov/pubmed/31973226
http://dx.doi.org/10.3390/ijms21030712
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