Cargando…
Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathologic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037725/ https://www.ncbi.nlm.nih.gov/pubmed/32023813 http://dx.doi.org/10.3390/ijms21030933 |
_version_ | 1783500490175152128 |
---|---|
author | Sechi, Stefano Frappaolo, Anna Karimpour-Ghahnavieh, Angela Piergentili, Roberto Giansanti, Maria Grazia |
author_facet | Sechi, Stefano Frappaolo, Anna Karimpour-Ghahnavieh, Angela Piergentili, Roberto Giansanti, Maria Grazia |
author_sort | Sechi, Stefano |
collection | PubMed |
description | Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer, breast cancer, glioma, and colorectal cancer. Overexpression of GOLPH3 correlates with poor prognosis in multiple tumor types including 52% of breast cancers and 41% to 53% of glioblastoma. Roles of GOLPH3 in tumorigenesis may correlate with several cellular activities including: (i) regulating Golgi-to-plasma membrane trafficking and contributing to malignant secretory phenotypes; (ii) controlling the internalization and recycling of key signaling molecules or increasing the glycosylation of cancer relevant glycoproteins; and (iii) influencing the DNA damage response and maintenance of genomic stability. Here we summarize current knowledge on the oncogenic pathways involving GOLPH3 in human cancer, GOLPH3 influence on tumor metabolism and surrounding stroma, and its possible role in tumor metastasis formation. |
format | Online Article Text |
id | pubmed-7037725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70377252020-03-10 Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer Sechi, Stefano Frappaolo, Anna Karimpour-Ghahnavieh, Angela Piergentili, Roberto Giansanti, Maria Grazia Int J Mol Sci Review Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer, breast cancer, glioma, and colorectal cancer. Overexpression of GOLPH3 correlates with poor prognosis in multiple tumor types including 52% of breast cancers and 41% to 53% of glioblastoma. Roles of GOLPH3 in tumorigenesis may correlate with several cellular activities including: (i) regulating Golgi-to-plasma membrane trafficking and contributing to malignant secretory phenotypes; (ii) controlling the internalization and recycling of key signaling molecules or increasing the glycosylation of cancer relevant glycoproteins; and (iii) influencing the DNA damage response and maintenance of genomic stability. Here we summarize current knowledge on the oncogenic pathways involving GOLPH3 in human cancer, GOLPH3 influence on tumor metabolism and surrounding stroma, and its possible role in tumor metastasis formation. MDPI 2020-01-31 /pmc/articles/PMC7037725/ /pubmed/32023813 http://dx.doi.org/10.3390/ijms21030933 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sechi, Stefano Frappaolo, Anna Karimpour-Ghahnavieh, Angela Piergentili, Roberto Giansanti, Maria Grazia Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title | Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title_full | Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title_fullStr | Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title_full_unstemmed | Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title_short | Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer |
title_sort | oncogenic roles of golph3 in the physiopathology of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037725/ https://www.ncbi.nlm.nih.gov/pubmed/32023813 http://dx.doi.org/10.3390/ijms21030933 |
work_keys_str_mv | AT sechistefano oncogenicrolesofgolph3inthephysiopathologyofcancer AT frappaoloanna oncogenicrolesofgolph3inthephysiopathologyofcancer AT karimpourghahnaviehangela oncogenicrolesofgolph3inthephysiopathologyofcancer AT piergentiliroberto oncogenicrolesofgolph3inthephysiopathologyofcancer AT giansantimariagrazia oncogenicrolesofgolph3inthephysiopathologyofcancer |