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Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer

Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathologic...

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Autores principales: Sechi, Stefano, Frappaolo, Anna, Karimpour-Ghahnavieh, Angela, Piergentili, Roberto, Giansanti, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037725/
https://www.ncbi.nlm.nih.gov/pubmed/32023813
http://dx.doi.org/10.3390/ijms21030933
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author Sechi, Stefano
Frappaolo, Anna
Karimpour-Ghahnavieh, Angela
Piergentili, Roberto
Giansanti, Maria Grazia
author_facet Sechi, Stefano
Frappaolo, Anna
Karimpour-Ghahnavieh, Angela
Piergentili, Roberto
Giansanti, Maria Grazia
author_sort Sechi, Stefano
collection PubMed
description Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer, breast cancer, glioma, and colorectal cancer. Overexpression of GOLPH3 correlates with poor prognosis in multiple tumor types including 52% of breast cancers and 41% to 53% of glioblastoma. Roles of GOLPH3 in tumorigenesis may correlate with several cellular activities including: (i) regulating Golgi-to-plasma membrane trafficking and contributing to malignant secretory phenotypes; (ii) controlling the internalization and recycling of key signaling molecules or increasing the glycosylation of cancer relevant glycoproteins; and (iii) influencing the DNA damage response and maintenance of genomic stability. Here we summarize current knowledge on the oncogenic pathways involving GOLPH3 in human cancer, GOLPH3 influence on tumor metabolism and surrounding stroma, and its possible role in tumor metastasis formation.
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spelling pubmed-70377252020-03-10 Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer Sechi, Stefano Frappaolo, Anna Karimpour-Ghahnavieh, Angela Piergentili, Roberto Giansanti, Maria Grazia Int J Mol Sci Review Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer, breast cancer, glioma, and colorectal cancer. Overexpression of GOLPH3 correlates with poor prognosis in multiple tumor types including 52% of breast cancers and 41% to 53% of glioblastoma. Roles of GOLPH3 in tumorigenesis may correlate with several cellular activities including: (i) regulating Golgi-to-plasma membrane trafficking and contributing to malignant secretory phenotypes; (ii) controlling the internalization and recycling of key signaling molecules or increasing the glycosylation of cancer relevant glycoproteins; and (iii) influencing the DNA damage response and maintenance of genomic stability. Here we summarize current knowledge on the oncogenic pathways involving GOLPH3 in human cancer, GOLPH3 influence on tumor metabolism and surrounding stroma, and its possible role in tumor metastasis formation. MDPI 2020-01-31 /pmc/articles/PMC7037725/ /pubmed/32023813 http://dx.doi.org/10.3390/ijms21030933 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sechi, Stefano
Frappaolo, Anna
Karimpour-Ghahnavieh, Angela
Piergentili, Roberto
Giansanti, Maria Grazia
Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title_full Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title_fullStr Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title_full_unstemmed Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title_short Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer
title_sort oncogenic roles of golph3 in the physiopathology of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037725/
https://www.ncbi.nlm.nih.gov/pubmed/32023813
http://dx.doi.org/10.3390/ijms21030933
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