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Genetic Dissection of Alzheimer’s Disease Using Drosophila Models

Alzheimer’s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid β (Aβ) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only available treatment remains sympto...

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Autores principales: Jeon, Youngjae, Lee, Jae Ha, Choi, Byoungyun, Won, So-Yoon, Cho, Kyoung Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037931/
https://www.ncbi.nlm.nih.gov/pubmed/32019113
http://dx.doi.org/10.3390/ijms21030884
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author Jeon, Youngjae
Lee, Jae Ha
Choi, Byoungyun
Won, So-Yoon
Cho, Kyoung Sang
author_facet Jeon, Youngjae
Lee, Jae Ha
Choi, Byoungyun
Won, So-Yoon
Cho, Kyoung Sang
author_sort Jeon, Youngjae
collection PubMed
description Alzheimer’s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid β (Aβ) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only available treatment remains symptomatic. Molecular understanding of the pathogenesis and progression of AD is necessary to develop disease-modifying treatment. Drosophila, as the most advanced genetic model, has been used to explore the molecular mechanisms of AD in the last few decades. Here, we introduce Drosophila AD models based on human Aβ and summarize the results of their genetic dissection. We also discuss the utility of functional genomics using the Drosophila system in the search for AD-associated molecular mechanisms in the post-genomic era.
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spelling pubmed-70379312020-03-10 Genetic Dissection of Alzheimer’s Disease Using Drosophila Models Jeon, Youngjae Lee, Jae Ha Choi, Byoungyun Won, So-Yoon Cho, Kyoung Sang Int J Mol Sci Review Alzheimer’s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid β (Aβ) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only available treatment remains symptomatic. Molecular understanding of the pathogenesis and progression of AD is necessary to develop disease-modifying treatment. Drosophila, as the most advanced genetic model, has been used to explore the molecular mechanisms of AD in the last few decades. Here, we introduce Drosophila AD models based on human Aβ and summarize the results of their genetic dissection. We also discuss the utility of functional genomics using the Drosophila system in the search for AD-associated molecular mechanisms in the post-genomic era. MDPI 2020-01-30 /pmc/articles/PMC7037931/ /pubmed/32019113 http://dx.doi.org/10.3390/ijms21030884 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jeon, Youngjae
Lee, Jae Ha
Choi, Byoungyun
Won, So-Yoon
Cho, Kyoung Sang
Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title_full Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title_fullStr Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title_full_unstemmed Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title_short Genetic Dissection of Alzheimer’s Disease Using Drosophila Models
title_sort genetic dissection of alzheimer’s disease using drosophila models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037931/
https://www.ncbi.nlm.nih.gov/pubmed/32019113
http://dx.doi.org/10.3390/ijms21030884
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