Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing. By forming high-affinity heterotriplex structures within the genome, PNAs have been used...

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Detalles Bibliográficos
Autores principales: Economos, Nicholas G., Oyaghire, Stanley, Quijano, Elias, Ricciardi, Adele S., Saltzman, W. Mark, Glazer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037966/
https://www.ncbi.nlm.nih.gov/pubmed/32046275
http://dx.doi.org/10.3390/molecules25030735

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